abstract：:This prospective pilot study was undertaken to test the efficacy of oral methyl-prednisolone (MP) therapy at spontaneous remission phase of type 1 diabetes in intervening the course of the disease. Twenty-five type 1 diabetic patients who were classified as having a spontaneous remission (honeymoon) were divided into ...

journal_title：Diabetes research and clinical practice

authors： Yilmaz MT,Devrim AS,Biyal F,Satman I,Arioğlu E,Dinççag N,Karsidağ K,Ozden I,Gürel N,Sipahioğlu F

更新日期：1993-02-01 00:00:00

abstract：:Possible factors that might influence the outcome of continuous subcutaneous insulin infusion (CSII) treatment were investigated in forty-nine, type 1, diabetic patients with median treatment of 3.25 years in routine diabetes care. In nine patients pump treatment was discontinued largely within the first 6 months. Pat...

journal_title：Diabetes research and clinical practice

authors： Wredling R,Lins PE,Adamson U

更新日期：1993-01-01 00:00:00

abstract：:For an epidemiological study of childhood diabetes, application forms for medical benefits filed in Osaka Prefecture were collected and analyzed. A total of 465 patients with childhood diabetes under 18 yr of age were identified during the period between 1978 and 1988; 371 (175 boys and 196 girls) of them were classif...

journal_title：Diabetes research and clinical practice

authors： Sasaki A,Okamoto N

更新日期：1992-12-01 00:00:00

abstract：:Insulin antibodies (IAA) can be detected in the serum of the majority of newly diagnosed IDDM patients prior to insulin therapy. In first degree relatives of IDDM patients, IAA are associated with an increased risk of development of IDDM. However, the disease specificity of IAA, detected by radiobinding assays, has no...

journal_title：Diabetes research and clinical practice

authors： Harrop M,Caudwell J,Stojanovski C,Colman PG

更新日期：1992-11-01 00:00:00

abstract：:The effect of insulin on the serum levels of the amino-terminal propeptide of type III procollagen (PIIINP) was investigated in patients with non-insulin-dependent diabetes mellitus, whose disease was unsatisfactorily controlled by oral drugs. Before insulin therapy the PIIINP values of the patients (3.2 +/- 1.3 micro...

journal_title：Diabetes research and clinical practice

authors： Sotaniemi EA,Stenbäck FG,Risteli L,Vuori JA,Rautio A,Huupponen R,Risteli J

更新日期：1992-09-01 00:00:00

abstract：:The preventive effect of an immunopotentiator, beta-1,6;1,3 D-glucan, on the development of diabetes and insulitis was studied in BB rats. The intravenous administration of 1 mg kg-1 week-1 of beta-1,6;1,3 D-glucan from the age of 4 weeks decreased the cumulative incidence of diabetes from 43.3% (13/30) to 6.7% (2/30)...

journal_title：Diabetes research and clinical practice

authors： Kida K,Inoue T,Kaino Y,Goto Y,Ikeuchi M,Ito T,Matsuda H,Elliott RB

更新日期：1992-08-01 00:00:00

abstract：:The aim of this study was to compare the effect of nasally administered glucagon in doses of 1 (A) and 2 mg (B), with 1 mg glucagon administered intramuscularly (C) in 12 C-peptide-negative IDDM patients. Spontaneous recovery (D) from insulin-induced hypoglycaemia in the same patients was used as reference. The mean a...

journal_title：Diabetes research and clinical practice

authors： Rosenfalck AM,Bendtson I,Jørgensen S,Binder C

更新日期：1992-07-01 00:00:00

abstract：:A retrospective analysis of blood glucose control was performed in 17 type 1 diabetic patients who regularly monitored their blood glucose concentration by visual strips over a period of 3-83 months. Analysis was performed by a patient management software loaded on a personal computer. In this cohort of patients the a...

journal_title：Diabetes research and clinical practice

authors： Bruttomesso D,Barberio S,Fongher C,Lisato G,Silvestri B,Briani G,Tiengo A,Del Prato S

更新日期：1992-06-01 00:00:00

abstract：:We have quantitatively assessed the percentage of lower limb arterio-venous (a-v) shunting using a radioisotopic technique and correlated it with autonomic neuropathy evaluated by cardiovascular tests. We have studied three groups of diabetic patients: Group A, 12 non-neuropathic subjects without foot lesions; Group B...

journal_title：Diabetes research and clinical practice

authors： Uccioli L,Mancini L,Giordano A,Solini A,Magnani P,Manto A,Cotroneo P,Greco AV,Ghirlanda G

更新日期：1992-05-01 00:00:00

abstract：:Glucose tolerance and insulin response were examined using a 100 g oral glucose tolerance test (OGTT) in 108 parents of 23 patients with insulin-dependent (IDDM) and 31 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose age of onset of diabetes was less than 35 years. Thirty-two age-matched healthy v...

journal_title：Diabetes research and clinical practice

authors： Matsuda A,Kuzuya T

更新日期：1992-04-01 00:00:00

abstract：:Xenotransplantation of pig islets under the kidney capsule (KC) of diabetic rats was performed. Natural preformed ACI rat anti-pig leukocytotoxicity, leukoagglutination and hemagglutination antibody titers ranged from Neat-1: 16, 1:8-1:32 and 1:128-1:256, respectively (n = 14). Normal ACI sera were non-toxic to pig is...

journal_title：Diabetes research and clinical practice

authors： Tze WJ,Tai J,Cheung SS

更新日期：1992-03-01 00:00:00

abstract：:To determine whether starvation affects the metabolism of glucagon-like peptide-1 (GLP-1), we measured the plasma levels of proglucagon-derived peptides and the biosynthesis and posttranslational processing of proglucagon in groups of six rats starved for 1, 3 and 5 days. The plasma levels of GLP-1 immunoreactivity (G...

journal_title：Diabetes research and clinical practice

authors： Takahashi J,Noma Y,Yoshimoto S,Fujita C,Shima K

更新日期：1992-03-01 00:00:00

abstract：:Lucigenin-enhanced chemiluminescence was examined as an index of neutrophil superoxide production in four groups of 20 subjects: controls with/without infection and type 1 diabetics with/without infection. At 5 mM glucose there was no significant difference in chemiluminescence output between neutrophils from the four...

journal_title：Diabetes research and clinical practice

authors： Tebbs SE,Lumbwe CM,Tesfaye S,Gonzalez AM,Wilson RM

更新日期：1992-02-01 00:00:00

abstract：:Changes of platelet aggregation in relation to macroangiopathy and to some of its risk factors were observed in microangiopathy-free, well-controlled type 1 diabetic males. Platelet aggregate ratio was generally lower in patients (n = 77) than in age-matched healthy subjects (n = 48). In the absence of cigarette smoki...

journal_title：Diabetes research and clinical practice

authors： Tóth L,Szénási P,Jámbor G,Kammerer L,Romics L

更新日期：1992-02-01 00:00:00

abstract：:To investigate the involvement of islet amyloid polypeptide (IAPP) and amyloid deposits in the pathophysiology of this disease, we studied the relationship between IAPP-derived amyloid deposition and the clinical features in type 2 diabetes mellitus. We examined pancreata obtained from 37 type 2 diabetic subjects and ...

journal_title：Diabetes research and clinical practice

authors： Ohsawa H,Kanatsuka A,Mizuno Y,Tokuyama Y,Takada K,Mikata A,Makino H,Yoshida S

更新日期：1992-01-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP/Amylin) is a novel peptide which was extracted from islet amyloid deposits in patients with non-insulin-dependent diabetes mellitus (NIDDM). However, its pattern of secretions and plasma concentrations under various conditions has not yet been made clear enough. In this study, we examin...

journal_title：Diabetes research and clinical practice

authors： Hanabusa T,Kubo K,Oki C,Nakano Y,Okai K,Sanke T,Nanjo K

更新日期：1992-01-01 00:00:00

abstract：:It is known that plasma low density lipoproteins (LDL) contain a great amount of vitamin E and that LDL enter cells via the specific receptor-mediated mechanism. In this study, we aimed to investigate the transport of alpha-tocopherol from plasma to tissues in subjects with non-insulin-dependent diabetes mellitus (NID...

journal_title：Diabetes research and clinical practice

authors： Kökoğlu E,Ulakoğlu E

更新日期：1991-12-01 00:00:00

abstract：:The effects of castration on diabetes-related renal growth and IGF-I regulation were studied. In the rat, prepubertal castration is associated with a normal or increased surge in plasma insulin-like growth factor I (IGF-I) at the time of 'puberty'. In order to determine the role of sex steroids in the development of d...

journal_title：Diabetes research and clinical practice

authors： Bach LA,Cox AJ,Jerums G

更新日期：1991-10-01 00:00:00

abstract：:To elucidate the mechanism responsible for the decreased insulin binding to erythrocytes in uremic patients, the effects of incubation with sera obtained from uremic patients or with methylguanidine, respectively, on insulin binding were examined. Insulin binding to erythrocytes from uremic patients was lower than tha...

journal_title：Diabetes research and clinical practice

authors： Lee JY,Iwama N,Watarai T,Yamasaki Y,Kawamori R,Kamada T

更新日期：1991-09-01 00:00:00

abstract：:In Madras city (India) 10,513 school students between 3 and 20 yr of age were investigated for glycosuria and its causes. While no previously known cases of diabetes mellitus of any type were encountered, four students (0.038%) in the survey population were found to have glycosuria. One (0.009%) had renal glycosuria, ...

journal_title：Diabetes research and clinical practice

authors： Bai PV,Krishnaswami CV,Chellamariappan M,Kumar GV,Subramaniam JR

更新日期：1991-08-01 00:00:00

abstract：:The prevalence, age at diagnosis, clinical characteristics and treatment of young diabetics, younger than 40 years were determined on the basis of a cross-sectional study of medical records of 2 health districts in Pahang, Malaysia. There were only 20 insulin-dependent diabetics (IDDM), prevalence 0.07 per 1000 inhabi...

journal_title：Diabetes research and clinical practice

authors： Lim TO

更新日期：1991-07-01 00:00:00

abstract：:Using prepubertal male New Zealand White rabbits, continuous subcutaneous insulin infusion (CSII), delivered by either an external or an implantable infusion device, resulted in significantly higher insulin antibody (I-Ab) production than bolus injection (BII). We tested the influence during CSII of (1) the insulin sp...

journal_title：Diabetes research and clinical practice

authors： Antony G,Cooper SG,Svejkar LC

更新日期：1991-04-01 00:00:00

abstract：:Recent clinical and experimental studies have suggested that diabetic patients may develop myocardial dysfunction in the absence of coronary heart disease and hypertension. In this study, the correlation between histopathological changes and myocardial dysfunction was studied in experimental diabetic rat hearts. Male ...

journal_title：Diabetes research and clinical practice

authors： Kita Y,Shimizu M,Sugihara N,Shimizu K,Yoshio H,Shibayama S,Takeda R

更新日期：1991-03-01 00:00:00

abstract：:There is evidence to suggest that hyperglycemia is required for the development of the microvascular complications of diabetes. However, the precise mechanism by which hyperglycemia might cause diabetic complications is not completely clear. One possibility is the increased activity of the polyol pathway. Capillary ba...

journal_title：Diabetes research and clinical practice

authors： Ramirez LC,Arauz C,Pruneda L,Hammon K,Rosenstock J,Raskin P

更新日期：1991-02-01 00:00:00

abstract：:Cultured cells derived from hamster insulinoma (In-111 R1 cells) were placed in 1.4 M dimethyl sulfoxide (Me2SO)-containing RPMI 1640 at 20 degrees C for 20 min. They were frozen to -40 degrees C at a cooling rate of 1.0 or 0.5 degrees C/min, subsequently to -80 degrees C at 3 degrees C/min with a programmable freezer...

journal_title：Diabetes research and clinical practice

authors： Ishihara K,Taniguchi H,Ejiri K,Baba S

更新日期：1991-02-01 00:00:00

abstract：:Comprehension of the effect of diabetes mellitus on auditory function has been hindered by the fact that previous studies have evaluated hearing function in heterogeneous groups of patients with diabetes mellitus, thus giving conflicting results. We have performed audiometric studies in 46 consecutive patients. 13 wit...

journal_title：Diabetes research and clinical practice

authors： Ferrer JP,Biurrun O,Lorente J,Conget JI,de España R,Esmatjes E,Gomis R

更新日期：1991-01-01 00:00:00

abstract：:The efficacy and safety of gliclazide (Diamicron) were studied in 29 NIDDM patients (19 men and 10 women aged 25-68 years) who failed to improve with diet or with diet plus a sulfonylurea. All patients were overweight and had fasting blood glucose levels consistently above 150 mg/dl (8.24 mmol/l). After withdrawal of ...

journal_title：Diabetes research and clinical practice

authors： Kilo C,Dudley J,Kalb B

更新日期：1991-01-01 00:00:00

abstract：:We evaluated the effects of thromboxane synthetase inhibitor, OKY-046, on urinary albumin and prostaglandin (PG) excretion in 14 patients with non-insulin-dependent diabetes mellitus (NIDDM). Urinary excretion of 6-keto-PGF1 alpha (a stable metabolite of PGI2), TXB2 (a stable metabolite of TXA2) and PGE2 in NIDDM pati...

journal_title：Diabetes research and clinical practice

authors： Tajiri Y,Inoguchi T,Umeda F,Nawata H

更新日期：1990-11-01 00:00:00

abstract：:In an attempt to clarify the mechanism of lipid metabolism during pregnancy, alpha 1-acid glycoprotein (alpha 1-AG) was analyzed in normal and diabetic pregnant women. Seventy-two determinations of serum alpha 1-AG levels were performed in 18 diabetic pregnant women and 82 determinations in 82 normal pregnant women in...

journal_title：Diabetes research and clinical practice

authors： Honda M,Omori Y,Minei S,Oshiyama T,Shimizu M,Sanaka M,Kohama T,Nakabayashi M,Hirata Y

更新日期：1990-10-01 00:00:00

abstract：:Because some aldose reductase inhibitor studies have demonstrated clinical improvement in scored neurological signs and symptoms of diabetic neuropathy, a prospective study of the effect on cardiovascular performance of sorbinil 250 mg/day for 12 months was conducted on patients with diabetic autonomic neuropathy who ...

journal_title：Diabetes research and clinical practice

authors： Roy TM,Broadstone VL,Peterson HR,Snider HL,Cyrus J,Fell R,Rothchild AH,Samols E,Pfeifer MA

更新日期：1990-08-01 00:00:00

abstract：:The present study was undertaken to compare the changes in islet cell antibodies (ICA), islet cell surface antibodies using rat insulinoma cells (RINr-ICSA), and anti-bovine serum albumin antibodies (BSA-Ab) in the clinical course of type 1 (insulin-dependent) diabetes. Sera were obtained from 57 patients with type 1 ...

journal_title：Diabetes research and clinical practice

authors： Yokota A,Yamaguchi Y,Ueda Y,Nakanishi T,Ikari N,Akazawa S,Miyake S,Nagataki S

更新日期：1990-07-01 00:00:00

abstract：:The influence of age on diabetic autonomic neuropathy was studied. In the present study autonomic neuropathy was assessed by cardiac beat-to-beat variation during deep breathing (BBV) and pupil area prior to photic stimulus (A1). In the studies on BBV a total of 440 subjects (11-82 years in age) were divided into thre...

journal_title：Diabetes research and clinical practice

authors： Kuroda N,Taniguchi H,Baba S,Yamamoto M

更新日期：1990-04-01 00:00:00

abstract：:Insulin release is influenced by the autonomic nervous system. Regarding parasympathetic control, previous reports have shown that regulation of insulin release is executed exclusively through muscarinic receptors in the pancreatic islets. In the present study, however, we examined the effect on insulin release at the...

journal_title：Diabetes research and clinical practice

authors： Ejiri K,Taniguchi H,Ishihara K,Hara Y,Baba S

更新日期：1990-03-01 00:00:00

abstract：:Fetal proislets (islet precursors) were transplanted to isogeneic diabetic CBA/H mice for analysis of their development and function post-transplant. Immunohistochemically, proislets contained scattered populations of insulin-, glucagon- and somatostatin-producing cells; following isotransplantation proislets develope...

journal_title：Diabetes research and clinical practice

authors： Simeonovic CJ,Mackie DJ,Wilson JD

更新日期：1990-03-01 00:00:00

abstract：:Thirty diabetics who had been receiving ordinary insulin were switched to S-lente insulin, a new mixture of four parts semilente and six parts ultralente insulin. Eight times a day, we measured the glucose, insulin, and C-peptide (CPR) in their blood. Those with more than 250 mg/dl postprandial glucose were designated...

journal_title：Diabetes research and clinical practice

authors： Ohneda A,Nihei J,Sasaki M

更新日期：1990-01-01 00:00:00

abstract：:The prevalence of obesity observed in this study seems higher than that reported in the previous study. This is probably due to the characteristics of the subjects studied, since they were subjects admitted for health examinations with possible selection. However, the observation in this study clearly indicated that o...

journal_title：Diabetes research and clinical practice

authors： Sasaki A

更新日期：1990-01-01 00:00:00

abstract：:We compared heart rates at the anaerobic threshold (AT) with age-adjusted heart rates in two groups of diabetics (DMY, mean age 31; and DMO, mean age 48) to ascertain whether the AT is useful for evaluating the intensity of exercise therapy for diabetics. In both the DMY and DMO groups the AT was reached at lower hear...

journal_title：Diabetes research and clinical practice

authors： Fujita Y,Kawaji K,Kanamori A,Matoba K,Yajima Y,Takeuchi A,Ishii K

更新日期：1990-01-01 00:00:00

abstract：:Circulating insulin antibodies at birth and the degree of maternal metabolic control were measured in 68 infants of insulin-treated diabetic mothers. Their correlation with neonatal B cell function and with the clinical features of the infants was evaluated in order to better understand their influence on fetal outcom...

journal_title：Diabetes research and clinical practice

authors： Fallucca F,Maldonato A,Iavicoli M,Di Rollo G,Di Biase N,Napoli A,De Vecchis P,Sciullo E,Gerlinì G,Pachi A

更新日期：1989-11-06 00:00:00

abstract：:Methylglyoxal and other alpha-oxoaldehydes are formed from glycolytic intermediates and may be involved in the development of diabetic microangiopathy. Glyoxalase I and glyoxalase II metabolise methylglyoxal to D-lactic acid, via the intermediate S-D-lactoylglutathione. The activities of the glyoxalase enzymes and the...

journal_title：Diabetes research and clinical practice

authors： Thornalley PJ,Hooper NI,Jennings PE,Florkowski CM,Jones AF,Lunec J,Barnett AH

更新日期：1989-08-01 00:00:00

abstract：:The issue of the peripheral resistance to insulin action has been getting a lot of attention over the last decade. The reason for this is that insulin is a major regulatory hormone and is involved in the metabolism of carbohydrates, lipids, protein and ions. To understand the pathophysiology of insulin resistance it i...

journal_title：Diabetes research and clinical practice

authors： Koffler M,Ramirez LC,Raskin P

更新日期：1989-08-01 00:00:00